According to the book "A Guide to Plant Poisoning of Animals in North America"
, it can be controlled by the use of herbicides, but it is important to remember that the seeds of many locoweeds can persist for at least 50 years. Repeated application of appropriate herbicides will generally be needed to control locoweed reemergence. A variety of herbicides are effective in controlling Astragalus and Oxytropis spp., including the approved chemicals clopyralid, dicamba, picloram, and triclopyr. The phenoxy herbicides 2,4-dichlorophenoxyacetic acid (2,4-D) and 2,4,5-trichlorophenoxyacetic acid (2,4,5-T) do control locoweeds as long as they are applied when the plants are actively growing. In all cases, it is most important to ensure the herbicide being used is approved for application in the area and that the manufacture's recommendations are followed.