Cedar-apple rust is a fungus disease of apple and cedar and spends parts of its life cycle on each host. It is caused by Gymnosporangium juniperi-virginianae. The fungus can infect leaves and fruit of most cultivars in the eastern region. A notable exception is 'Delicious', which is nearly immune. Find more information and tables of resistant cultivars in this article on Cedar-Apple Rust.
Answer provided by Alan R. Biggs, West Virginia University.